Frequency and distribution of genotypes of human papillomavirus in women treated in public hospitals in Culiacan, Sinaloa

Authors

Keywords:

Cervical cancer, HPV infection, Multiple HPV infection, PCR

Abstract

The human papillomavirus (HPV) is the causative agent of cervical cancer (CaCu), the fourth most common cancer in women in Mexico. There are several genotypes of HPV which are classified as high or low oncogenic risk viruses (HR-HPV, BR-HPV). There is little information in Sinaloa about the viral genotypes circulating among the female population. The objective of this work was to estimate the prevalence and multiple infections of HPV genotypes in women from Sinaloa. This is a descriptive, cross-sectional, observational and prospective study. Participants were selected and sampled during February 2023 to February 2024. DNA from endo-exocervical samples was extracted using the Jena Bioscience kit and the DNA was subsequently analyzed to identify the viral genome by PCR. The results show that the average age of the participating women was 41.4 years (95% CI: 38.6-44.2). The average onset of sexual life was 18.6 years (95% CI: 17.6-19.6), and the average age of menarche was 12.8 years (95% CI: 12.4-13.2). The prevalence of HPV infection was 33.3%. Of the 21 women who had STIs, 52.4% of their partners also developed this infection. The percentage distribution of infection by viral genotypes was 85% for HPV16, 30% for HPV11 and 20% for HPV81. 90% of women infected with HPV had multiple infections (p=0.026). The concordance analysis showed that HPV 16 genotype, which was the most prevalent, has statistically significant agreement with HPV31, -39, -52, -58 and -59 genotypes.

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Author Biographies

  • Osuna-Espinoza G.E., Facultad de Ciencias Químico Biológicas-UAS, México.

    Graduated from the FCQB as a QFB, she has participated as a speaker in research activities at the International Congress of the XXVII SUMMER OF SCIENTIFIC AND TECHNOLOGICAL RESEARCH OF THE PACIFIC with the topic: Association of polymorphisms in the DSP and TERT genes with mortality in patients with COVID -19. She has training in cell culture techniques and has been a member of the MEXICAN PHARMACEUTICAL ASSOCIATION. She obtained the QFB degree through the defense of her thesis

  • Méndez-Martínez R. S., Instituto Nacional de Cancerología, México.

    Researcher at the National Cancer Institute in the Basic Research Subdirectorate. Training as a Biologist from the UNAM, as well as a master's degree in Molecular Biology and a Doctorate in Biotechnology, from the UNAM and the FCQB-UAS, respectively. Member of the SNI level I, She has various publications in JCR magazines

  • Durán-Pérez S. A., Facultad de Ciencias Químico Biológicas-UAS, México.

    Training as a QFB, with a master's degree in Biomedical Sciences and a PhD in Biotechnology from the FCQB-UAS, member of the SNI level C. Currently a Full-Time Professor and Researcher, FCQB-UAS

  • Báez-Flores M. E., Facultad de Ciencias Químico Biológicas-UAS, México.

    TTraining as a QFB, with a master's degree and doctorate from CIAD-Hermosillo. Member of the SNI level 1; member of the NAB of professors of the Postgraduate in Biomedical Sciences. With extensive experience in research and national and international recognition for her scientific career.

  • Vázquez-Vega S., Centro Médico Nacional Siglo XXI, IMSS, México.

    Researcher at the Epidemiological and Health Services Research Unit, National Medical Center Siglo XXI, Mexican Institute of Social Security, Mexico City. Member of the SNI level 1

  • Osuna-Ramírez I., Facultad de Ciencias Químico Biológicas-UAS, México.

    PITC Holder C, FCQB-UAS, with training as a Mathematical Physicist from the Autonomous University of Sinaloa, with a postgraduate degree in Health from the INSP, Cuernavaca, Morelos, and a Doctorate in Health Economics from the Universite Claude Bernard in Lyon, France. Member of the NAB of professors of the Postgraduate in Biomedical Sciences, member of the SNI level I, with wide national and international recognition for his scientific career.

  • Rendón-Maldonado J.G., Facultad de Ciencias Químico Biológicas-UAS, México.

    Master and Doctor in Sciences, Experimental Pathology, Dept. of Infectomics and Molecular Pathogenesis, Cinvestav–IPN, Mexico City. Currently is a Professor and Researcher at Universidad Autónoma de Sinaloa. Focused on studying the biology, pathogenesis and diagnosis of infectious diseases caused by bacteria, parasites and virus, including DENV, HPV, CMV, HIV, RotV, NorV and SARS-Cov-2

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Human papillomavirus

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Published

2024-07-12

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No. 2 (2024): QUIBIOUAS Revista de Ciencias Químico Biológicas

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Scientific articles

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How to Cite

Osuna-Espinoza, G. E., Méndez-Martínez, R. S., Durán-Pérez, S. A., Báez-Flores, M. E., Vázquez-Vega, S., Osuna-Ramírez, I., & Rendón Maldonado, J. G. (2024). Frequency and distribution of genotypes of human papillomavirus in women treated in public hospitals in Culiacan, Sinaloa. QUIBIOUAS Revista De Ciencias Químico Biológicas, 2, 11-22. https://revistas.uas.edu.mx/index.php/QBU/article/view/652