Analysis of biochemical markers in pregnant women with and without preeclampsia who attend the Center for Research and Teaching in Health Sciences and to the Civil Hospital of Culiacan

Abstract

The preeclampsia (PE) is a syndrome characterized by increased blood pressure (>140/90 mmHg) accompanied by proteinuria in a 24-hour urine collection (>300 mg) and multiorgan involvement that jeopardizes the viability of both the mother and the fetus. This syndrome affects between 2-8% of all pregnant women worldwide. The objective of this study was to analyze biochemical markers in pregnant women with and without preeclampsia attending a regional hospital during the period 2018 to 2019. It is a cross sectional study of case-control type. We were able to recruit 4 cases vs. 50 controls. Among the cases, a subclassification emerged into PE 75% (3) and preeclampsia with severity data (PEds) 25% (1). The cases presented a blood pressure (BP) of 153/96.75+13.11/5.25 mmHg vs 124/78.42+18.41/13.43 mmHg in controls, showing statistical association (p=0.001 and p=0.003 for systolic and diastolic blood pressure, respectively). Creatinine was 1.93+8.60 mg/dL vs 0.59+0.06 mg/dL for controls and cases,
respectively, with no statistical association (p=0.759). Glutamic oxaloacetic transaminase was 28.73+23.70 mg/dL y 24.00+10.00 mg/dL for controls and cases, respectively, without statistical significance (p=0.739). Glutamic pyruvic transaminase was 28.21+27.20 mg/dL vs. 27.33+17.21 mg/dL for controls and cases respectively, with no significant association (p=0.957). Regarding the 24-hour urine protein level (PtO 24 h), cases presented 2,858.8+4,317.1 vs 267.5+239.6 mg in controls, finding no significant association with the development of PE (p=0.316). No patient experienced complications requiring hospitalization due to maternal-fetal management.