Diagnostic performance and correlation of 12-hour vs. 24-hour urinary protein in pregnant women with preeclampsia at a Mexican Obstetric Hospital

Authors

Keywords:

Preeclampsia, Proteinuria, Early diagnosis, Urine collection

Abstract

Preeclampsia (PE) affects up to 8 % of pregnancies. In cases of non-severe PE, diagnosis requires the presence of proteinuria, with the 24-hour urine collection (RO24H) being the gold standard. However, shorter collection times could improve clinical efficiency. The objective of this project was to evaluate the accuracy of 12-hour urine collection (12HUR) compared to 24-hour urine collection (24HUR). A cross-sectional observational study was conducted that included 103 patients with hypertensive disorders admitted to the Women's Hospital between May 1 and October 31, 2022. RO12H was collected in a labeled container within 24 hours. RO12H demonstrated higher sensitivity and specificity compared to RO24H, with a diagnostic efficiency of 88.35% and a correlation coefficient of r = 0.60 (p < 0.000), with a threshold of >150 mg/12 hours. RO12H shows a moderate positive correlation with RO24H and offers potential advantages by reducing catheterization time, infection risk, and hospitalization costs associated with PE management.

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Author Biographies

  • Gámez-Meza A.H., Women’s Hospital of Culiacan

    He is a Researcher at the Women’s Hospital of Culiacan and holds a Bachelor's Degree in Gynecology and Obstetrics from the Autonomous University of Sinaloa. He has published 5 articles in indexed journals and 5 in peer-reviewed journals, with a total of 4 citations to date and an h-index of 2. He has participated in 3 national and international congresses. Throughout his career, he has supervised 1 undergraduate thesis, 1 master’s thesis, and 1 doctoral thesis in the field of medicine. Additionally, he works in Maternal-Fetal Medicine.
    Contact email: alanhamidgamez.fm@uas.edu.mx

  • Terán-Cabanillas E., Faculty of Nutritional and Gastronomic Sciences UAS

    He is a Professor/Researcher at the Autonomous University of Sinaloa and holds a Ph.D. in Sciences awarded by the Research Center in Food and Development (CIAD). He is a Level 1 member of the National System of Researchers (SNII), an Honorary Researcher recognized by the SSIT, and holds a PRODEP Profile. He has published 20 articles in indexed journals and 20 in peer-reviewed journals, accumulating 347 citations to date and an h-index of 9. He has participated in 5 national and international conferences. Throughout his career, he has supervised undergraduate, master’s, and doctoral theses.

    Contact e-mail: eteranc@uas.edu.mx

  • Murillo-Llanes J., Women’s Hospital, Health Services of Sinaloa

    He is a Professor/Researcher at the Women’s Hospital, Health Services of Sinaloa, and holds a Master's degree in Medical Sciences from the Autonomous University of Sinaloa. He is a Level 1 member of the National System of Researchers (SNII). He has published 15 articles in indexed journals and 30 in peer-reviewed journals, with a total of 617 citations and an h-index of 11 to date. He has participated in 4 national and international conferences. Throughout his career, he has supervised theses in the field of Health Sciences. Additionally, he conducts research on preeclampsia.
    Contact e-mail: invhgc@gmail.com

  • Peña-García G.M., Autonomous University of Sinaloa

    She is a Professor/Researcher at the Universidad Autónoma de Sinaloa and holds a Ph.D. in Nursing as well as a Doctorate in Education from Universidad Andrés Bello in Santiago, Chile. She is a Level 2 member of the National System of Researchers (SNII), an Honorary Researcher at SSIT, and holds a PRODEP Profile. She has published 12 articles in indexed journals and 28 in peer-reviewed journals, with a total of 135 citations to date and an h-index of 6. She has participated in 51 national and international conferences. Throughout her academic career, she has supervised 98 undergraduate theses, 28 master’s theses, and 16 doctoral dissertations in the field of Educational and Behavioral Sciences. As an additional note, she has 32 years of research experience, ranging from clinical case studies to doctoral-level investigations.
    Contact e-mail: gpena@uas.edu.mx

  • Magaña-Ordoríca D., Autonomous University of Sinaloa

    She is a Professor/Researcher at the Autonomous University of Sinaloa and holds a Master’s degree in Sciences from the Research Center for Food and Development (CIAD), A.C. She is a member of the SSIT as a Researcher and holds a PRODEP Profile. She has published 7 articles in indexed journals and 3 in peer-reviewed journals, with a total of 200 citations and an h-index of 5 to date. She has participated in 1 national and international conference. Throughout her career, she has supervised 2 undergraduate theses in the field of Health Sciences.
    Contact e-mail: dmagana@uas.edu.mx

  • Heusinkveld J., Vanderbilt University.

    Heusinkveld is a Board Certified specialist in Female Pelvic Medicine and Reconstructive surgery with Banner - University Medical Center Tucson’s Department of Obstetrics and Gynecology. He has over 25 years of experience in surgical and nonsurgical treatment of pelvic floor disorders such as pelvic organ prolapse and urinary incontinence, and vesico-vaginal fistula. He also practices general gynecology.
    Contact email: jheusinkveld@arizona.edu

  • Castro-Apodaca F.J., Faculty of Nutrition and Gastronomic Sciences

    He is a Professor/Researcher at the Faculty of Nutrition and Gastronomy Sciences and holds a Master's degree in Food Safety. He is currently a subspecialty student in Gynecologic Urology at the Fray Antonio Alcalde Civil Hospital of Guadalajara. He is a Candidate-level member of the National System of Researchers (SNII) and a recognized researcher by the SSIT. He has published 38 articles in indexed journals and 38 in peer-reviewed journals, accumulating 105 citations to date and an h-index of 4. He has participated in 8 national and international conferences. Throughout his career, he has supervised 3 undergraduate theses and 12 master's theses in the field of Health Sciences (Nutrition, Food Safety, Gynecology and Obstetrics, and Gynecologic Urology).

    As an additional note, he is a peer reviewer for BMJ, Revista Chilena de Ginecología y Obstetricia, European Journal of Obstetrics & Gynecology and Reproductive Biology, and Delinees.

    Contact e-mail: francisco.castroapodaca@uas.edu.mx

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portada 1089

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Published

2025-07-10

Data Availability Statement

The data are available from the corresponding author upon request.

Issue

No. 4 (2025): QUIBIOUAS Revista de Ciencias Químico Biológicas

Section

Scientific articles

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Copyright (c) 2025 QUIBIOUAS, Journal of Biological Chemical Sciences

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How to Cite

Gámez Meza, A. H. ., Terán Cabanillas, E., Murillo Llanes, J., Peña García, G. M. ., Magaña Ordorica, D. ., Heusinkveld, J. ., & Castro Apodaca , F. J. (2025). Diagnostic performance and correlation of 12-hour vs. 24-hour urinary protein in pregnant women with preeclampsia at a Mexican Obstetric Hospital. QUIBIOUAS, Journal of Biological Chemical Sciences, 4, 8-14. https://revistas.uas.edu.mx/index.php/QBU/article/view/1089

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